Synergistic action of calcium-lonophores and hyperthermia is best interpreted as thermal enhancement of calcium toxicity
✍ Scribed by G. J. J. Stege; P. K. Wierenga; A. W. T. Konings; H. H. Kampinga
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 725 KB
- Volume
- 155
- Category
- Article
- ISSN
- 0021-9541
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✦ Synopsis
It has been shown that no relation exists between [CaL'li and hyperthermic cell killing, although heat-induced increase of [Ca2+li can he observed in some cell lines. When ionophores are used, dose-dependent rises in [Ca"], may be found. Beyond a certain threshold of ionophore-induced increases in iCaL+li, cells may be killed. Different threshold levels of [CaL+], exist in different cell lines. Hyperthermia can act synergistically with calcium ionophores to potentiate cell killing. Since there is no causal relation between [Ca'+l, and heat toxicity, this synergism can be explained as heat enhanced Ca' ' toxicity. In the current report, it is shown that both ionophore-induced Ca'+ toxicity (37OC) and its potentiation by heat are dependent on extracellular calcium and related to sustained increases in [Ca'+],.