Synergism of the ATF/CRE Site and GC Box in the Housekeeping Na,K-ATPase α1 Subunit Gene Is Essential for Constitutive Expression

Regulation of Na,K-ATPase α1 subunit gen

Regulation of Na,K-ATPase α1 subunit gene transcription in response to low K+: Role of CRE/ATF- and GC box-binding proteins

✍ Gang Wang; Kiyoshi Kawakami; Gregory Gick 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB

## Abstract Na,K‐ATPase expression is upregulated in mammalian cells as a consequence of persistent inhibition of Na,K‐ATPase enzymatic activity by low external K^+^. We previously demonstrated that exposure of neonatal rat cardiac myocytes to low K^+^ increased Na,K‐ATPase α1 subunit mRNA content