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Synergism in vitro of lovastatin and miconazole as anti-leishmanial agents

✍ Scribed by Penny A. Haughan; Michael L. Chance; L.John Goad


Book ID
115782818
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
932 KB
Volume
44
Category
Article
ISSN
0006-2952

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Pyrimethamine, an antimalarial drug, was found to be able to inhibit both enzymes (DHFR-TS and PTR1) of the leishmanial folate pathway, although this effect in vivo appears only in relatively high concentrations. To reach the parasites inside macrophage cells, where they are sheltered, targeted drug