SYNERGISM BETWEEN INTERFERON-γ AND cAMP IN INDUCTION OF HEPATOCYTE GROWTH FACTOR IN HUMAN SKIN FIBROBLASTS
✍ Scribed by Eiichi Gohda; Kazunori Kuromitsu; Tetsuhiko Matsunaga; Masahiro Miyazaki; Itaru Yamamoto
- Book ID
- 115596433
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 192 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1043-4666
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Induction of hepatocyte growth factor/scatter factor (HGF/SF) may be one of the critical steps in organ regeneration, wound healing, and embryogenesis. We previously reported the production of HGF/SF from various human leukemia cell lines and a high level of the growth factor in blood and bone marro
## Abstract The effect of hepatocyte growth factor/scatter factor (HGF/SF) on the proliferation of human skin fibroblasts was examined. At concentrations above 1.0 ng/ml, both native and recombinant human HGF/SF stimulated the DNA synthesis determined by [^3^H]thymidine incorporation, which was com