Syndrome of acrofacial dysostosis, cleft lip/palate, and triphalangeal thumb in a brazilian family
β Scribed by Richieri-Costa, A. ;Gollop, Thomaz R. ;Colletto, G. M. D. D. ;Opitz, John M.
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 290 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0148-7299
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π SIMILAR VOLUMES
## Abstract We report on a Brazilian woman, born to consanguineous (first cousin) parents (F = 1/16) and presenting cleft lip/palate, ectodermal dysplasia, interdigital webbing, and other malformations. Parental consanguinity and possible recurrence in sibs suggest autosomal recessive inheritance.
## Abstract Cleft lip and/or palate (CL/P) is a common congenital malformation with a complex etiology, as many genes and environmental factors have been shown to play a role in craniofacial development. We used a genetic mapping approach to analyze a family with multiplex CL/P. A genomeβwide scan