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Synchronous small cell carcinoma and adenocarcinoma of the lung representing different retinoblastoma tumor suppressor protein status

✍ Scribed by S. Yoshida; E. Shimizu; M. Kawanishi; Y. Nakamura; S. Sone; T. Sano; T. Uyama


Book ID
110603643
Publisher
Springer
Year
1998
Tongue
English
Weight
395 KB
Volume
3
Category
Article
ISSN
1341-9625

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We examined the p53 status of 108 NSCLCs compared to the expression of MLH1 and MSH2 proteins. p53 overexpression was demonstrated by IHC in 64% of patients examined, whereas p53 mutations were detected in 43%. Twenty-two percent of mutations were located outside of the hot-spot (exons 5-8) area. p5