Synchronous colorectal carcinoma: Presence and concordance of DNA mismatch repair enzyme expression
β Scribed by Harry R. Aslanian; David A. Ahlquist; Stephen N. Thibodeau; Patrick C. Roche; Jonathan J. Harrington; Lawrence J. Burgart
- Book ID
- 119425353
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 146 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0016-5085
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Most colorectal adenomas and carcinomas arise in the setting of chromosomal instability and progressive loss of heterozygosity. Approximately 15-20% of colorectal neoplasms arise through a distinct genetic pathway characterized by microsatellite instability (MSI) and frequent loss of expression of o
Fourteen Italian families affected with hereditary nonpolyposis colorectal cancer (HNPCC) were screened for germline mutations at three DNA mismatch repair (MMR) genes, MSH2, MLH1, and GTBP, by using a combination of different methods that included an in vitro synthesized protein assay, single-stran