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Synchronization of Glucose-Induced Ca2+Transients in Pancreatic β-Cells by a Diffusible Factor

✍ Scribed by Eva Grapengiesser; Erik Gylfe; Bo Hellman


Book ID
115583217
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
60 KB
Volume
254
Category
Article
ISSN
0006-291X

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The effect of carbachol on the cytoplasmic Ca2+ concentration [( Ca2+]i) was studied in insulin-releasing mouse pancreatic beta cells hyperpolarized by the K(+)-channel-activating agent diazoxide. By mobilizing intracellular Ca2+, carbachol induced an initial [Ca2+]i transient, which was more than t