Synaptonemal complex damage as a measure of genotoxicity at meiosis
✍ Scribed by James W. Allen; Patricia A. Poorman; Lorraine C. Backer; James B. Gibson; Barbara Westbrook-Collins; Montrose J. Moses
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 473 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0742-2091
No coin nor oath required. For personal study only.
✦ Synopsis
Synaptonemal complex aberrations can provide a sensitive measure of chemical-specific alterations to meiotic chromosomes. Mitomycin C, cyclophosphamide, amsacrine, ellipticine, colchicine, vinblastine sulfate, and cis-platin exposures in mice have been shown to cause various patterns of synaptonemal complex structural damage and synaptic irregularity. These effects are suggestive of abnormal homologue pairing/synapsis/recombination effects which, theoretically, could be implicated in mechanisms leading to aneuploidy and other potentially heritable chromosomal disorders.