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syn-Selective additions to Garner aldehyde: synthesis of a potent glucosylceramide synthase inhibitor

✍ Scribed by Arifa Husain; Bruce Ganem

Book ID: 104252291
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 139 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)02096-8

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✦ Synopsis

Highly syn-selective additions of aryl Grignard reagents to Garner aldehyde 5 are reported, making possible a practical, asymmetric synthesis of the potent glucosylceramide synthase inhibitor 3.

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