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SYMPOSIUM REVIEW: Revealing the structural basis of action of hERG potassium channel activators and blockers

โœ Scribed by Matthew Perry; Michael Sanguinetti; John Mitcheson

Book ID
110117273
Publisher
Cambridge University Press
Year
2010
Tongue
English
Weight
612 KB
Volume
588
Category
Article
ISSN
0022-3751

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โœ Etsuko Katoh; Hideki Nishio; Tatsuya Inui; Yuji Nishiuchi; Terutoshi Kimura; Shu ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 389 KB ๐Ÿ‘ 2 views

A topochemical model to explain the biological activity of dendrotoxin-I (DTX-I), a potent blocker for potassium channels, was developed by searching common spatial arrangements of functionally important residues between DTX-I, alpha-dendrotoxin, dendrotoxin-K, BgK, ShK, and charybdotoxin. The first