“Symmetry” in the synthesis of the a-ring of a vitamin D hybrid analogue with significant transactivation activity: A combinatorial sequence of regioselective propiolate-ene, catalytic enantioselective epoxidation and carbonyl-ene cyclization reactions

✍ Scribed by Koichi Mikami; Ayako Osawa; Akira Isaka; Eiji Sawa; Masaki Shimizu; Masahiro Terada; Noboru Kubodera; Kimie Nakagawa; Naoko Tsugawa; Toshio Okano

• Book ID: 104259016
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 259 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)00272-x

✦ Synopsis

The combinalion of the regioselective propiolate-ene reaction, catalytic enantioselective epoxidation and catalytic ,~nantieselective carbonyl-ene cyclization completes the synthesis of the A ring of the hybrid 19-nor-22-o~a D 3 analogue (1), which shows the significant activity in transactivation.