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Syk kinase inhibitors for rheumatoid arthritis: Trials and tribulations

✍ Scribed by Maarten Boers

Book ID
101653838
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
34 KB
Volume
63
Category
Article
ISSN
0004-3591

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Treatment of rheumatoid arthritis with a
Treatment of rheumatoid arthritis with a syk kinase inhibitor: A twelve-week, randomized, placebo-controlled trial
✍ Michael E. Weinblatt; Arthur Kavanaugh; Ruben Burgos-Vargas; Ara H. Dikranian; G πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 165 KB πŸ‘ 2 views

## Abstract ## Objective Spleen tyrosine kinase (Syk) has been identified as an important modulator of immune signaling in B cells and cells bearing Fcγ‐activating receptors. R788, a prodrug of active metabolite R406, has been shown to be an inhibitor of Syk kinase, active in a variety of in vitro