SWIFT detection of SPIO-labeled stem cells grafted in the myocardium

✍ Scribed by Rong Zhou; Djaudat Idiyatullin; Steen Moeller; Curt Corum; Hualei Zhang; Hui Qiao; Jia Zhong; Michael Garwood

• Book ID: 102533005
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 471 KB
• Volume: 63
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.22378

✦ Synopsis

Abstract

We report initial results from studies using sweep imaging with Fourier transformation (SWIFT) to detect superparamagnetic iron oxide (SPIO) particle–labeled stem cells in the rat heart. In experiments performed on phantoms containing titanium balls or SPIO–labeled cells, frequency‐shifted signals surrounding the paramagnetic objects produced a pileup artifact visualized by SWIFT. Total signal intensity was retained to a much greater extent by SWIFT as compared to gradient echo imaging. SWIFT imaging of excised and in vivo hearts showed (a) reduced blooming artifact as compared with gradient echo imaging, which helped reduce ambiguity in the detection of SPIO–labeled cells; (b) enhancement of off‐resonance signals relative to the background in the imaginary component of images; and (c) detailed myocardial anatomy in magnitude images, which provided anatomic reference. These features suggest SWIFT can facilitate the detection of SPIO–laden cells in the cardiovascular system. Magn Reson Med 63:1154–1161, 2010. © 2010 Wiley‐Liss, Inc.