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Swallowing and speech ability after treatment for head and neck cancer with targeted intraarterial versus intravenous chemoradiation

✍ Scribed by Lisa A. Newman; K. Thomas Robbins; Jeri A. Logemann; Alfred W. Rademaker; Cathy L. Lazarus; Annette Hamner; Stephanie Tusant; Cheng Fang Huang

Book ID: 102232414
Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 98 KB
Volume: 24
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.10000

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✦ Synopsis

Abstract

Objective

RADPLAT (concurrent selective supradose intraarterial cisplatin and external‐beam irradiation) delivers extraordinarily high cisplatin concentration to head and neck structures. This study was designed to quantify and compare RADPLAT and systemic chemoradiation treatment effects on swallowing and speech.

Methods

Videofluorographic swallowing studies and articulation testing of 14 head and neck cancer patients treated with RADPLAT were compared with 16 treated with systemic chemoradiation 1 month after treatment.

Results

RADPLAT and systemic chemoradiation patients did not differ significantly on most swallow outcome measures, and there was significantly less aspiration on 1 and 3 mL liquid for RADPLAT individuals. Speech function was comparable except for RADPLAT's significantly worse /s, z/ productions.

Conclusions

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