SV40-transformed human cells fail to grow in zinc concentrations which permit normal human fibroblast proliferation
✍ Scribed by J. Epstein
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 638 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0021-9541
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✦ Synopsis
Abstract
Zinc is a metal known to be required for normal growth of both cells and organisms. When normal and SV~40~‐transformed human tumor cells are plated and grown in medium containg zinc sulfate, a significant fraction of the transformed cells fail to grow at zinc concentrations which are relatively nontoxic to the normal fibroblasts. Although cultured cells respond to certain metallic ions by incresing their metallothionein content, no difference in the ability of normal and transformed cells to produce metallothionein in response to zinc exposure could be detected, thus ruling out this mechanism as a basic for the differing abilities of the cells to grwo in zinc in vitro. These results suggest that zinc may be capable of differntially regulating the growth of normal and SV~40−~ transformed human fibroblasts.