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SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype. I. Mechanisms responsible for hyperinvasivess and resistance to anti-invasive action of TGFβ

✍ Scribed by Nelson K. S. Khoo; John F. Bechberger; Trevor Shepherd; Shari L. Bond; Keith R. McCrae; G. Scot Hamilton; Peeyush K. Lala

Publisher: John Wiley and Sons
Year: 1998
Tongue: French
Weight: 337 KB
Volume: 77
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19980729)77:3<429::aid-ijc20>3.0.co;2-1

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SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype. II. Changes in gap junctional intercellular communication

✍ Nelson K. S. Khoo; Yuchun Zhang; John F. Bechberger; Shari L. Bond; Kathleen Hum 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 384 KB

Poor gap junctional intercellular communication (GJIC) has been associated with uncontrolled cell growth and neoplasia. We have successfully propagated normal first trimester invasive extravillous trophoblast (EVT) cells, and have produced premalignant EVT lines after SV40 Tag transformation: RSVT-2