SV40 Large T antigen mutant data base
β Scribed by James M. Pipas
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 91 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0920-9069
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## Abstract The continued presence of simian virus 40 (SV40), a monkey polyomavirus, in man is confirmed by the regular detection of SV40βspecific antibodies in 5β10% of children who are unlikely to have received contaminated polioβvaccines. The aim of our experiments was to find cellular immunolog
The SV40 T antigen causes numerical (aneuploidy) and structural (aberrations) chromosome damage when expressed in human diploid fibroblasts. This chromosome damage precedes the acquisition of neoplastic traits such as anchorage independence, colony formation in reduced serum growth factors, immortal