SV-IV, a major protein secreted from rat seminal vesicle epithelium, promotes lymphocyte cytotoxic activity against the lymphoblastoid Raji cell line in human peripheral blood mononuclear cells
✍ Scribed by Gianfranco Peluso; Magda Marchese; Annita Furgi; Marilena Ranieri; Silvana Russo Spena; Giampietro Ravagnan; Maria Pia Fuggetta; Raffaele Porta; Vittoria Metafora; Salvatore Metafora
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- French
- Weight
- 107 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
The treatment of human peripheral blood mononuclear cells (PBMC) with micromolar concentrations of SV-IV, a major protein secreted from the rat seminal vesicle epithelium, promotes in this cell population a marked cytotoxic activity against the Raji lymphoblastoid cell line. This activity is apparently due to cell-to-cell contact interactions. The expression of HLA DR on Raji cells has a modulatory effect on the SV-IV-induced cytotoxic activity. The experimental evidence strongly suggests that the cytotoxic effector cells are functionally activated NK cells.