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Sustained T cell Rap1 activation protects against Experimental Autoimmune Encephalomyelitis (EAE) via modulation of T cell responses

✍ Scribed by G Franco Salinas, S Krausz, W Dontje, P P Tak…


Book ID
120690431
Publisher
BioMed Central
Year
2010
Tongue
English
Weight
118 KB
Volume
8
Category
Article
ISSN
1479-5876

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## Abstract The regulatory role of programmed death 1 (PD‐1) was investigated in the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Typical EAE could be induced by immunization without pertussis toxin (PTX) in PD‐1‐null but not in wild‐type (W