Sustained Release of Diclofenac from Polymer-Containing Suppository and the Mechanism Involved
โ Scribed by Azechi, Y.; Ishikawa, K.; Mizuno, N.; Takahashi, K.
- Book ID
- 124102510
- Publisher
- Informa plc
- Year
- 2000
- Tongue
- English
- Weight
- 125 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0363-9045
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๐ SIMILAR VOLUMES
Data from sustained-release and enteric-coated oral formulations, and the suppository formulation of diclofenac sodium are fitted simultaneously using NONMEM ยฎ and the general linear model, ADVAN 5. Absorption and disposition parameters, serum levels, and absorption profiles were determined. The in
Weakly basic drugs and their salts exhibit a drop in aqueous solubility at high pH conditions, which can result in low and incomplete release of these drugs from sustained release formulations. The objective of this study is to modulate matrix microenvironmental pH by incorporation of acidic polymer