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Sustained Polymeric Delivery of Gene Silencing Antisense ODNs, siRNA, DNAzymes and Ribozymes: In Vitro and In Vivo Studies

✍ Scribed by Khan, Alim; Benboubetra, Mustapha; Sayyed, Pakeeza Z.; Wooi Ng, Keng; Fox, Stephen; Beck, Gordon; Benter, Ibrahim F.; Akhtar, Saghir


Book ID
125539506
Publisher
Informa plc
Year
2004
Tongue
English
Weight
801 KB
Volume
12
Category
Article
ISSN
1061-186X

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## Abstract Small interfering RNA (siRNA) molecules achieve sequence‐specific gene silencing through the RNA interference (RNAi) mechanism. Here, live‐cell and live‐animal bioluminescent imaging (BLI) is used to directly compare luciferase knockdown by unmodified and nuclease‐stabilized siRNAs in r