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Sustained activation of c-jun-N-terminal kinase plays a critical role in arsenic trioxide-induced cell apoptosis in multiple myeloma cell lines

✍ Scribed by Tomohiro Kajiguchi; Kazuhito Yamamoto; Shinsuke Iida; Ryuzo Ueda; Nobuhiko Emi; Tomoki Naoe


Book ID
108583637
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
233 KB
Volume
97
Category
Article
ISSN
1347-9032

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## Abstract Molecular mechanisms underlying chemotherapeutic agent–induced apoptosis in sarcoma cells are not well known. Induction of apoptosis is regulated by several components including mitogen‐activated protein kinases (MAPKs) comprising ERK, p38MAPKs, and c‐Jun N‐terminal kinase (JNK). In the