Sustained-action tablets prepared by employing a spray-drying technique for granulation
✍ Scribed by Saul S. Kornblum
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 365 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
A spray-drying technique has been investigated which provides a free-flowing powder with decreased dissolution rate for the medicinal agent when compressed into tablets. The fine powder (16150 p ) obtained by this process has proved to possess excellent drug distribution and when tableted offers good reproducibility of drug release for consecutive batches. The consistency of the drug-release pattern is tabulated and the drug-release phenomena discussed. The effect of aging on the release rate of the sustained-action tablets has been investigated. Keyphrases 0 Sustained-action tablets-spray-drying technique Spray-dried powder-sustained-action matrix 0 Particle-size determination-spray-dried powder 0 Dissolution rates, tabletsspray-dried powder effect ~ * Marketed as Methocel, Dow Chemical Co.