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Susceptibility to typhoid fever is associated with a polymorphism in the cystic fibrosis transmembrane conductance regulator (CFTR)

✍ Scribed by Esther van de Vosse; Soegianto Ali; Adriëtte W. de Visser; Charles Surjadi; Suwandhi Widjaja; Albert M. Vollaard; Jaap T. van Dissel


Book ID
106134120
Publisher
Springer
Year
2005
Tongue
English
Weight
171 KB
Volume
118
Category
Article
ISSN
0340-6717

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Cystic fibrosis (CF) is characterised as a single-gene disorder with a simple, autosomal recessive mode of inheritance. However, translation of CFTR genotype into CF phenotype is influenced by nucleotide sequence variations at multiple genetic loci, and individuals heterozygous for CFTR mutations ar