Disrupted posttranscriptional regulation
✍
Samuel W. Lukowski; Cristina Bombieri; Ann E. O. Trezise
📂
Article
📅
2011
🏛
John Wiley and Sons
🌐
English
⚖ 502 KB
Cystic fibrosis (CF) is characterised as a single-gene disorder with a simple, autosomal recessive mode of inheritance. However, translation of CFTR genotype into CF phenotype is influenced by nucleotide sequence variations at multiple genetic loci, and individuals heterozygous for CFTR mutations ar