Susceptibility of clinical isolates ofcampylobacter pylorito 24 antimicrobial and anti-ulcer agents

✍ Scribed by Y. Glupczynski; M. Delmee; C. Bruck; M. Labbe; V. Avesani; A. Burette

• Publisher: Springer
• Year: 1988
• Tongue: English
• Weight: 338 KB
• Volume: 4
• Category: Article
• ISSN: 0393-2990
• DOI: 10.1007/bf00144743

✦ Synopsis

Forty-nine isolates of Campylobacler pylori were tested for their susceptibility to twenty antibiotics and four anti-ulcer a~ents by an agar dilution technique. Penicillin and amoxycillin were the most active drugs ('MICg0, 0.06 Ixg/ml); erythromycin, cefazolin, minocycline, ciprofloxacin, ofloxacin and gentamicin were sligthtly less active (MICg0, G 1 l~g/ml). Moderate activity was found for doxycyclin, rifampin, nitrofurantoin, norfloxacin, pefloxacin, enoxacin, paromomycin, metronidazole and tinidazole. All strains were resistant to trimethoprim (MIC > 512 I~g/ml). N.alidixic ,acid (MICg0, > 256 lxg/ml) and colistin (MICgo, > 64 Izg/ml) had little to fro .activity. Of four anti-ulcer drugs, only bismuth subcitrate showed activity (MICo0, 64 Ixg/ml).

Strains resistant to all 4-quinolones were found in patients who had previously received ofloxaein as part of a clinical trial aimed at eradication of C. pylori.

These isolates remained susceptible to amoxycillin, tetracyclines and to other classes of antibiotics.