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Susceptibility for schizophrenia is not influenced by a functional insertion/deletion variant in the promoter of the serotonin transporter gene

✍ Scribed by G. Stöber; Susanne Jatzke; Armin Heils; Gerd Jungkunz; Elisabeth Fuchs; Michael Knapp; Peter Riederer; Klaus-Peter Lesch

Publisher
Springer-Verlag
Year
1998
Tongue
English
Weight
68 KB
Volume
248
Category
Article
ISSN
1433-8491

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Analysis of a novel functional polymorphism within the promoter region of the serotonin transporter gene (5-HTT) in Brazilian patients affected by bipolar disorder and schizophrenia
✍ de Oliveira, Jo�o R. Mendes; Otto, Paulo A.; Vallada, Homero; Lauriano, Val�ria; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 11 KB 👁 2 views

It has been suggested that the serotonin transporter (5-hydroxytryptamine-transporter or 5-HTT) may be involved in the pathogenesis of affective disorders. Recently, Collier et al. (1996) found that the frequency of the low-activity short variant (s) of the 5-HTT-linked polymorphic region (5-HTTLPR)