## Abstract Little is known about the effects of intravenous abuse of cocaine, especially on the inner ear. We report on a 26βyearβold man who presented to our outpatient department with a sudden severe hearing loss after intravenous injection of cocaine. The audiogram on admission showed symmetric
Susac's syndrome: Intratympanic therapy for hearing loss and a review of the literature
β Scribed by Brianna K. Crawley; Abby Close; Cecilia Canto; Jeffrey P. Harris
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 65 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0023-852X
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β¦ Synopsis
Abstract
Two cases of Susac's Syndrome are presented with a discussion of treatment modalities for the associated severe sensorineural deafness. Patients were managed with high dose oral steroids, anticoagulants and immunosuppressive drugs. The addition of intratympanic methylprednisolone injections were added to one patient's regimen with initial improvement but subsequent relapse and progression to profound deafness. The management of Susac's syndrome is difficult and still in need of innovative methods as the standard treatment continues to be ineffective in the long term. Laryngoscope, 119:141β144, 2009
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## Abstract ## Objectives/Hypothesis: To determine the evidence for different etiologies of sudden sensorineural hearing loss (SSNHL) identified by clinical diagnostic tests in the adult population. ## Study Design: Systematic literature review. ## Methods: Review of MEDLINE (1950βOctober 2009
About 20% of all human conceptuses are estimated to be trisomic and trisomy of all chromosomes remains a common cause of early fetal loss. Uniparental disomy (UPD) has been reported for most human chromosomes and may be an underrecognized contributor to embryonic lethality. To investigate the contri