Survivin expression in “low-risk” and “high-risk” myelodysplastic syndromes
✍ Scribed by Umberto Gianelli; Nicola Stefano Fracchiolla; Agostino Cortelezzi; Caterina Pellegrini; Federica Savi; Alessia Moro; Maria Grazia Grimoldi; Giorgio Lambertenghi Deliliers; Guido Coggi; Silvano Bosari
- Book ID
- 105988863
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 166 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0939-5555
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Apoptosis is dysregulated in patients with myelodysplastic syndrome (MDS) and acute myelogenous leukaemia (AML). FLIP (FLICE (FAS-associated death-domain-like IL-1 beta-converting enzyme)-inhibitory protein) has been described as an anti-apoptotic protein. Here, we characterize the expression level
## Abstract ## BACKGROUND: Thrombocytopenia is very common in myelodysplastic syndrome (MDS); however, its clinical impact in low‐risk patients remains controversial. ## METHODS: The authors analyzed the incidence and prognostic significance of thrombocytopenia at diagnosis in 2565 de novo MDS p