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Survivin and Aurora B kinase, two interesting targets for cancer therapy

✍ Scribed by A. Molla; M. Delacour-Larose; A. Valette; S. Dimitrov


Book ID
119598541
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
99 KB
Volume
6
Category
Article
ISSN
1359-6349

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## Abstract Histone deacetylase (HDAC) inhibitors, such as valproic acid (VPA), constitute a novel class of anticancer agents that cause an increase in acetylated histones and thus restore the expression of dormant tumor‐suppressor and other genes related to cell differentiation, cell‐cycle arrest

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## Abstract ## Background. Aurora kinase A (AURKA) is amplified with varying incidence in multiple human cancers including head and neck squamous cell carcinoma (HNSCC). We investigated whether AURKA is a potential therapeutic target in HNSCC. ## Methods. We conducted an immunohistochemical anal