Survivin and Aurora B kinase, two interesting targets for cancer therapy
β Scribed by A. Molla; M. Delacour-Larose; A. Valette; S. Dimitrov
- Book ID
- 119598541
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 99 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1359-6349
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The Aurora A kinase belongs to serine/threonine group of kinases, well known for its role in cell cycle, especially in the regulation of mitosis. Numerous substrates of Aurora A kinase have been identified, which are predominantly related to cell cycle progression while some of them are transcriptio
## Abstract Histone deacetylase (HDAC) inhibitors, such as valproic acid (VPA), constitute a novel class of anticancer agents that cause an increase in acetylated histones and thus restore the expression of dormant tumorβsuppressor and other genes related to cell differentiation, cellβcycle arrest
## Abstract ## Background. Aurora kinase A (AURKA) is amplified with varying incidence in multiple human cancers including head and neck squamous cell carcinoma (HNSCC). We investigated whether AURKA is a potential therapeutic target in HNSCC. ## Methods. We conducted an immunohistochemical anal