𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Survival of childhood leukemia in Singapore

✍ Scribed by Quah, Thuan Chong; Sun, Li; Chew, Fook Tim; Yeoh, Allen; Lee, Bee Wah

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
523 KB
Volume
26
Category
Article
ISSN
0098-1532

No coin nor oath required. For personal study only.

✦ Synopsis

The objective of this study was to evaluate the treatment outcome of children with acute leukemias at a university hospital in Singapore. Between January 1988 and lanuary 1994, 66 children were treated, comprising 13 cases of acute myeloid leukemia (AML) and 53 of acute lyrnphoblastic leukemia (ALL). The 2-year disease-free survival (DFS) was computed according to the Kap-Ian-Meier method. The results showed that the survival for AML was poor, with a 2-year DFS of only 30%. The major cause of death for AML was leukemia and leukemia-related complications, such as hemorrhage and se-vere infections. In contrast, a 62% 2-year DFS was achieved for ALL. It was found that marked hepatosplenomegaly (enlarged liver andlor spleen a10 cm below the costal margin) at presentation correlated with a significantly shortened survival in our patients with ALL. The major cause for treatment failure in ALL was recurrence of disease. We conclude that the DFS for our patients with ALL at 2 years was fair. The treatment results for AML were poor, but the numbers are too small to make any definite conclusions.

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