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Surrogate-Based Optimization of Expensive Flowsheet Modeling for Continuous Pharmaceutical Manufacturing

✍ Scribed by Boukouvala, Fani; Ierapetritou, Marianthi G.

Book ID
120827930
Publisher
Springer US
Year
2013
Tongue
English
Weight
842 KB
Volume
8
Category
Article
ISSN
1872-5120

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## Abstract In this work a methodology is presented for the rigorous optimization of nonlinear programming problems in which the objective function and (or) some constraints are represented by noisy implicit black box functions. The special application considered is the optimization of modular proc