Surgical salvage nasopharyngectomy for recurrent nasopharyngeal carcinoma: A multivariate analysis of prognostic factors

✍ Scribed by Alexander C. Vlantis; Hing Sang Chan; Michael C. F. Tong; Brian K. H. Yu; Michael K. M. Kam; C. Andrew van Hasselt

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 93 KB
• Volume: 33
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.21585

✦ Synopsis

Background. The purpose of this study was to identify independent prognostic factors that influenced local relapse-free survival (LRFS) and overall survival (OS) of patients who underwent salvage surgery for residual or recurrent nasopharyngeal carcinoma (NPC).

Methods. Ninety-seven patients who had been treated with radiotherapy or chemoradiotherapy for NPC underwent a nasopharyngectomy for a residual or recurrent local tumor between November 1987 and June 2007. The subsequent minimum follow-up was 2 years. Univariate and multivariate analyses were performed to identify prognostic factors for LRFS and OS.

Results. The 5-year LRFS and OS was 46.7% and 51.9%, respectively. On multivariate analysis for LRFS and OS, respectively, recurrent regional disease (hazard ratio [HR], 3.245; p ¼ .008) and (HR, 4.990; p ¼ .001), and positive surgical margins (HR, 5.963; p ¼ .000), and (HR, 4.912; p ¼ .000) were independent prognostic factors.

Conclusion. In patients undergoing surgical salvage nasopharyngectomy for residual or recurrent NPC, positive surgical margins have an independent negative influence on LRFS and OS. V