Systemic therapy for advanced gastrointe
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Edward J. Kim; Mark M. Zalupski
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Article
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2011
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John Wiley and Sons
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English
β 88 KB
## Abstract Progression on firstβline therapy with imatinib in gastrointestinal stromal tumors (GIST) is caused by either initial resistance or more often a secondary mutation in tyrosine kinases KIT or PDGFR. Therapies in development for imatinibβresistant GIST include agents that target KIT/PDGFR