Surgical approach and sandwich radiotherapy for resectable rectal cancer: Advantages and problems

✍ Scribed by Aurelio Picciocchi; Paolo Magistrelli; Claudio Coco; Riccardo Masetti; Giuliano Roncolini; Pasquale Perrotti; Numa Cellini; Vincenzo Valentini

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 266 KB
• Volume: 48
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930480530

✦ Synopsis

One hundred and twelve patients with locally advanced adenocarcinoma of the rectum have been treated with a protocol of adjuvant radiotherapy from 198 1 to 1989. Radiotherapy was administered with a "sandwich" method at a dosage of 2700 cGy preoperatively and of 1800 cGy post-operatively .

Only patients in stages B and C have been considered for results.

Postoperative morbidity has been 16% and postoperative mortality 2.7%. Local failure was seen in 20% of patients without significant differences by stage, location, grading and operative technique. Distant metastases were seen in 31% of patients. Five-year actuarial survival was 49% and respectively 58% in stage B and 38% in stage C ( P < 0.01). Compared with a series of historical controls treated with surgery alone, the local recurrence rate was 20% vs. 26%, the distant metastases rate was 31% vs. 38% and the five-year actuarial survival rate was 49% vs. 36% ( P > 0.01).