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Surgery in the DREZ for Refractory Neuropathic Pain After Spinal Cord/Cauda Equina Injury

✍ Scribed by Marc Sindou


Book ID
113952785
Publisher
Elsevier
Year
2011
Tongue
English
Weight
425 KB
Volume
75
Category
Article
ISSN
1878-8750

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We have previously shown that activation of the ATP-gated ion channel subtype P2X 4 receptors (P2X 4 Rs) in the spinal cord, the expression of which is upregulated in microglia after nerve injury, is necessary for producing neuropathic pain. The upregulation of P2X 4 Rs in microglia is, therefore, a