Surfing on a retrograde wave: how does Shiga toxin reach the endoplasmic reticulum?

[Current Topics in Microbiology and Immu

[Current Topics in Microbiology and Immunology] Ricin and Shiga Toxins Volume 357 || How Ricin and Shiga Toxin Reach the Cytosol of Target Cells: Retrotranslocation from the Endoplasmic Reticulum

✍ Mantis, Nicholas 📂 Article 📅 2011 🏛 Springer Berlin Heidelberg 🌐 German ⚖ 698 KB

In May of 2011, Western Europe experienced a severe outbreak of Shiga toxin (Stx)-producing E. coli (STEC) that culminated in more than 3200 cases and 39 deaths. While Stx is not the only virulence factor associated with STEC, it is certainly the primary determinant associated with the onset of hem