Surface Segregation Assessment In Poly(ε-caprolactone)-poly(ethylene glycol) Multiblock Copolymer Films

✍ Scribed by Stefania Cometa; Federica Chiellini; Irene Bartolozzi; Emo Chiellini; Elvira De Giglio; Luigia Sabbatini

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 642 KB
• Volume: 10
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200900284

✦ Synopsis

Abstract

The ability to predict the in vivo performance of multiblock‐copolymer‐based biomaterials is crucial for their applicability in the biomedical field. In this work, XPS analysis of PCL‐PEG copolymers was carried out, as well as morphological and wettability evaluations by SEM and CA measurements, respectively. XPS analysis on films equilibrated in PBS demonstrated a further enrichment in the PEG component on the surface. Copolymer films obtained by casting using different solvents showed a dependence in segregation according to the solvent employed. Cell adhesion tests demonstrated the importance of copolymer segregation and rearrangement in a wet environment, with a dependence of these phenomena on the copolymer molecular weight.

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