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Surface reactive polymers for special applications in nucleic acid synthesis

✍ Scribed by H. Seliger; R. Bader; E. Birch-Hirschfeld; Z. Földes-Papp; K.H. Gührs; M. Hinz; R. Rösch; C. Scharpf

Book ID: 103997787
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 639 KB
Volume: 26
Category: Article
ISSN: 1381-5148
DOI: 10.1016/1381-5148(95)00059-o

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✦ Synopsis

This publication reviews work done in the authors' laboratories on the functionalization of surface-reactive polymers and their application as a basis for the preparation of oligonucleotides of extended length, larger number or quantity. In addition to nonporous particulate materials (silicagel microbeads; polystyrene-grafted polytetrafluoroethylene particles) special focus is on recent work describing the introduction of spacered amino groups into polypropylene films and the preparation of oligonucleotides on polypropylene surface. A prototype apparatus is shown, for use with a four-column DNA synthesizer, that permits the semi-mechanized preparation of a one-dimensional array of oligonucleotides of variant sequence.

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