Surface plasmon resonance-biosensor detects the diversity of responses against epidermal growth factor in various carcinoma cell lines

Decreased mitogenic response to epiderma

Decreased mitogenic response to epidermal growth factor in human squamous cell carcinoma lines overexpressing epidermal growth factor receptor owing to limiting amounts of the adaptor protein Grb2: Rescue by retinoic acid treatment

✍ David L. Crowe; Kenneth J. Tsang 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 163 KB 👁 1 views

## Abstract Growth factor receptors of the tyrosine kinase family regulate proliferation of a variety of cell types. In some human cancers, the epidermal growth factor receptor (EGFR) and its ligands often are overexpressed, leading to both constitutive and autocrine activation. Intracellular signa