Surface Modification of Biomaterials. Methods Analysis and Applications

✍ Scribed by R. Williams (Eds.)

• Publisher: Woodhead Publishing
• Year: 2011
• Tongue: English
• Leaves: 426
• Series: Woodhead Publishing Series in Biomaterials
• Edition: 1
• Category: Library

✦ Synopsis

The surface modification of biomaterials plays a significant role in determining the outcome of biological-material interactions. With the appropriate modification a material's surface can be tailored to improve biocompatibility, adhesion and cell interactions. Consequently surface modification is vital in the development and design of new biomaterials and medical devices. Surface modification of biomaterials reviews both established surface modifications and those still in the early stages of research and discusses how they can be used to optimise biological interactions and enhance clinical performance.

Part one begins with chapters looking at various types and techniques of surface modification including plasma polymerisation, covalent binding of poly (ethylene glycol) (PEG), heparinisation, peptide functionalisation and calcium phosphate deposition before going on to examine metal surface oxidation and biomaterial surface topography to control cellular response with particular reference to technologies, cell behaviour and biomedical applications. Part two studies the analytical techniques and applications of surface modification with chapters on analysing biomaterial surface chemistry, surface structure, morphology and topography before moving onto discuss modifying biomaterial surfaces to optimise interactions with blood, control infection, optimise interactions with soft tissues, repair and regenerate nerve cells, control stem cell growth and differentiation and to optimise interactions with bone.

The distinguished editor and international team of contributors to Surface modification of biomaterials have produced a unique overview and detailed chapters on a range of surface modification techniques which will provide an excellent resource for biomaterials researchers and scientists and engineers concerned with improving the properties of biomaterials. It will also be beneficial for academics researching surface modification.

• Reviews both established surface modifications and those still in the early stages of research and how they can be used to optimise biological interactions and enhance clinical performance
• Studies analytical techniques and applications of surface modification with chapters assessing biomaterial surface chemistry, surface structure, morphology and topography
• Discusses modifying biomaterial surfaces to optimise interactions with blood and soft tissues and also to repair and regenerate nerve cells and control infection

✦ Table of Contents

Content:
Front matter, Pages i-iii
Copyright, Page iv
Contributor contact details, Pages xi-xiv, Rachel Williams, Endre Szili, Rob Short, David Steele, James Bradley, A. Rhodes, S.S. Sandhu, Mr S.J. Onis, Xiaobin Zhao, James M. Courtney, Louise S. Birchall, Honglei Qu, Rein V. Ulijn, Luigi De Nardo, Fabio Ganazzoli, Giuseppina Raffaini, Roberto Chiesa, Judith A Juhasz, Serena M. Best, Victoria R. Kearns, Rebecca J. McMurray, et al.
Preface, Pages xv-xvi, Rachel Williams
1 - Surface modification of biomaterials by plasma polymerization, Pages 3-39, E.J. Szili, R.D. Short, D.A. Steele, J.W. Bradley
2 - Surface modification of biomaterials by covalent binding of poly(ethylene glycol) (PEG), Pages 39-55, A. Rhodes, S.S. Sandhu, S.J. Onis
3 - Surface modification of biomaterials by heparinisation to improve blood compatibility, Pages 56-77, X. Zhao, J.M. Courtney
4 - Surface modification of biomaterials by peptide functionalisation, Pages 78-101, L.S. Birchall, H. Qu, R.V. Ulijn
5 - Metal surface oxidation and surface interactions, Pages 102-142, L. Denardo, G. Raffaini, F. Ganazzoli, R. Chiesa
6 - Surface modification of biomaterials by calcium phosphate deposition, Pages 143-169, J.A. Juhasz, S.M. Best
7 - Biomaterial surface topography to control cellular response: technologies, cell behaviour and biomedical applications, Pages 169-201, V.R. Kearns, R.J. Mcmurray, M.J. Dalby
8 - Techniques for analysing biomaterial surface chemistry, Pages 205-232, J. Yang, M.R. Alexander
9 - Techniques for analyzing biomaterial surface structure, morphology and topography, Pages 232-255, N.S. Murthy
10 - Modifying biomaterial surfaces to optimise interactions with blood, Pages 255-283, A. De Mel, Y. Rafiei, B.G. Cousins, A.M. Seifalian
11 - Modifying biomaterial surfaces with bioactives to control infection, Pages 284-309, H.J. Griesser, K. Vasilev, H. Ys, S.A. Al-Bataineh
12 - Modifying biomaterial surfaces to optimise interactions with soft tissues, Pages 309-325, J. Gough
13 - Modifying biomaterial surfaces for the repair and regeneration of nerve cells, Pages 325-343, M.A. Mateos-Timoneda, J.A. Planell, E. Engel
14 - Modifying biomaterial surfaces to control stem cell growth and differentiation, Pages 344-364, K.H. Smith, J.W. Haycock
15 - Modifying biomaterial surfaces to optimise interactions with bone, Pages 365-400, R.L. Sammons
Index, Pages 401-415