Surface-Imprinted, Thermosensitive, Core-Shell Nanosphere for Molecular Recognition

✍ Scribed by Du Young Ko; Hwa Jeong Lee; Byeongmoon Jeong

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 329 KB
• Volume: 27
• Category: Article
• ISSN: 1022-1336
• DOI: 10.1002/marc.200600259

✦ Synopsis

Abstract

Summary: The D‐glucose imprinted core‐shell nanosphere with an average size of ≈60 to 80 nm showed a significant preference for the binding of D‐glucose than the non‐imprinted core‐shell nanosphere. Depending on temperature, the binding site in the shell with N‐isopropylacrylamide oligomer underwent a significant change in binding affinity. In addition, the D‐glucose imprinted core‐shell nanosphere showed a two times higher affinity for D‐glucose than L‐glucose, suggesting chiral recognition of the binding site. The core‐shell nanosphere reported here is a good biomimetic model system with a well‐defined morphology, high surface area, and variable binding affinity through a change in temperature.

D‐glucose imprinted core‐shell nanospheres showed excellent binding over the non‐imprinted core‐shell nanosphere.

magnified imageD‐glucose imprinted core‐shell nanospheres showed excellent binding over the non‐imprinted core‐shell nanosphere.