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Surface immobilization of hexa-histidine-tagged adeno-associated viral vectors for localized gene delivery

✍ Scribed by Jang, J-H; Koerber, J T; Gujraty, K; Bethi, S R; Kane, R S; Schaffer, D V

Book ID: 109855484
Publisher: Nature Publishing Group
Year: 2010
Tongue: English
Weight: 383 KB
Volume: 17
Category: Article
ISSN: 0969-7128
DOI: 10.1038/gt.2010.81

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## Abstract ## Background Conventional strategies of gene therapy using viral vectors result in suboptimal localization and potentially dangerous distal spread of vector. We hypothesized that localized delivery of adenoviral gene vectors could be achieved from a polyurethane (PU) film through a me