Surface Functionalization of Porous Resorbable Scaffolds by Covalent Grafting

✍ Scribed by Martina Källrot; Ulrica Edlund; Ann-Christine Albertsson

• Book ID: 102472952
• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 449 KB
• Volume: 8
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200700329

✦ Synopsis

Abstract

Resorbable porous scaffold discs and solid films were prepared from poly[(1,5‐dioxepan‐2‐one)‐co‐(L‐lactide)] and poly[(ε‐caprolactone)‐co‐(L‐lactide)]. The surfaces of the scaffolds were functionalized to increase their hydrophilicity. A total of 90 samples were prepared to cover all important combinations of experimental and material factors, and all experimental data were fitted by a partial least square model. As a result of grafting, the porous discs and solid films exhibited a tremendous increase in wettability. The functionalized discs were hygroscopic so that water was instantly absorbed and thoroughly wet the substrates.

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