Surface functional group dependence on apatite formation on self-assembled monolayers in a simulated body fluid

✍ Scribed by Tanahashi, Masami ;Matsuda, Takehisa

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 789 KB
• Volume: 34
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(19970305)34:3<305::aid-jbm5>3.0.co;2-o

✦ Synopsis

Self-assembled monolayers (SAMs) of alkanethiols having with the COOH group. The SAMs of the alkanethiols with CH 3 , PO 4 H 2 , COOH, CONH 2 , OH, and NH 2 terminal groups the CONH 2 , OH, and NH 2 groups possessed much weaker formed on a gold surface via sulfur attachment were soaked inducing powers than the former two SAMs. Little weight in a simulated body fluid (SBF), whose ion concentrations change was observed for the methyl-group-terminated alkawere nearly equal to those of human blood plasma, at 37ЊC nethiol SAM. The growth rates increased with time, irrespecfor up to 40 days. The effect of their terminal functional tive of the terminal group species among apatite formationgroups on apatite formation was assessed using X-ray photo-inducing groups. During the experimental observation electron spectroscopic (XPS) measurement and a quartz crys-period, the following relationship held. The growth rate detal microbalance (QCM) technique. The Ca and P atoms were creased in the order PO 4 H 2 Ͼ COOH ӷ CONH 2 ȃ OH Ͼ detected, of which element intensities increased with time, on NH 2 ӷ CH 3 ȃ 0. Since negatively charged groups strongly SAMs except for the alkanethiol having the methyl terminal induced apatite formation but the positively charged group group. The Ca/P atomic ratios of the apatites formed on the did not, it can be said that the apatite formation initiated via SAMs ranged from around 1.0 to around 1.3. The most potent calcium ion-adsorption upon complexation with a negative inducer for apatite formation, judged from the growth rate surface-charged group may be dominant in biomaterial calci-(micrometers per day) calculated from the weight change fication where ionic species directly contact the biomaterial during QCM measurement, was the SAM of the alkanethiol surface in body fluids.