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Surface-enhanced Raman spectroscopic study of amsacrine and amsacrine–DNA interactions

✍ Scribed by Thomas F. Barton; Ralph P. Cooney; William A. Denny

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
382 KB
Volume
23
Category
Article
ISSN
0377-0486

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✦ Synopsis

Abstract

Surface‐enhanced Raman scattering (SERS) spectroscopy has been employed to study the interaction of intercalating ligands with DNA. SERS was used to obtain spectra of acridine, aminoacridine, the 9‐anilinoacridine amsacrine and related compounds at associated solution concentrations down to 1 μM. A major advantage of SERS was the near absence of fluorescence normally inherent in solution spectra of these compounds. SERS spectra of amsacrine–DNA complexes at various ligand/base pair ratios showed free ligand concentrations consistent with those calculated from the binding constant, and showed that the less strongly interacting acridine was largely unbound even at high ligand/base pair ratios.

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