Surface-energy dependent contact activation of blood factor XII
โ Scribed by Avantika Golas; Purnendu Parhi; Ziad O. Dimachkie; Christopher A. Siedlecki; Erwin A. Vogler
- Book ID
- 108070073
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 497 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0142-9612
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## Abstract Activation of human blood plasma coagulation by contact with hydrophilic or hydrophobic surfaces (procoagulants) is dominated by kallikrein (Kal)โmediated activation of the blood zymogen FXII (Hageman Factor). Mathematical modeling of prekallikrein (PK)โdeficient plateletโpoor plasma (d
A mathematical model of contact activation of blood coagulation was developed and analysed. The model variables are concentrations of factor XIIa, kallikrein and activated high-molecular-weight kininogen. Concentrations of active factors were shown to depend on the activating signal value in a hyste