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Surface-energy dependent contact activation of blood factor XII

โœ Scribed by Avantika Golas; Purnendu Parhi; Ziad O. Dimachkie; Christopher A. Siedlecki; Erwin A. Vogler


Book ID
108070073
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
497 KB
Volume
31
Category
Article
ISSN
0142-9612

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## Abstract Activation of human blood plasma coagulation by contact with hydrophilic or hydrophobic surfaces (procoagulants) is dominated by kallikrein (Kal)โ€mediated activation of the blood zymogen FXII (Hageman Factor). Mathematical modeling of prekallikrein (PK)โ€deficient plateletโ€poor plasma (d

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A mathematical model of contact activation of blood coagulation was developed and analysed. The model variables are concentrations of factor XIIa, kallikrein and activated high-molecular-weight kininogen. Concentrations of active factors were shown to depend on the activating signal value in a hyste