Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) of low molecular weight organic compounds and synthetic polymers using zinc oxide (ZnO) nanoparticles
✍ Scribed by Takehiro Watanabe; Hideya Kawasaki; Tetsu Yonezawa; Ryuichi Arakawa
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 234 KB
- Volume
- 43
- Category
- Article
- ISSN
- 1076-5174
- DOI
- 10.1002/jms.1385
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✦ Synopsis
Abstract
We have developed surface‐assisted laser desorption/ionization mass spectrometry using zinc oxide (ZnO) nanoparticles with anisotropic shapes (ZnO‐SALDI‐MS). The mass spectra showed low background noises in the low m/z, i.e. less than 500 u region. Thus, we succeeded in SALDI ionization on low molecular weight organic compounds, such as verapamil hydrochloride, testosterone, and polypropylene glycol (PPG) (average molecular weight 400) without using a liquid matrix or buffers such as citric acids. In addition, we found that ZnO‐SALDI has advantages in post‐source decay (PSD) analysis and produced a simple mass spectrum for phospholipids. The ZnO‐SALDI spectra for synthetic polymers of polyethylene glycol (PEG), polystyrene (PS) and polymethylmethacrylate (PMMA) showed the sensitivity and molecular weight distribution to be comparable to matrix‐assisted laser desorption/ionization (MALDI) spectra with a 2,5‐dihydroxybenzoic acid (DHB) matrix. ZnO‐SALDI shows good performance for synthetic polymers as well as low molecular weight organic compounds. Copyright © 2008 John Wiley & Sons, Ltd.