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Surface and transport properties of acrylic polymers influencing drug release from porous matrices

โœ Scribed by Carli, F.; Capone, G.; Colombo, I.; Magarotto, L.; Motta, A.

Book ID
120540263
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
1004 KB
Volume
21
Category
Article
ISSN
0378-5173

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Weakly basic drugs and their salts exhibit a drop in aqueous solubility at high pH conditions, which can result in low and incomplete release of these drugs from sustained release formulations. The objective of this study is to modulate matrix microenvironmental pH by incorporation of acidic polymer