Sur une tentative d'unification des théaories quantiques de la cancérisation par les polyacènes. II: Le rôle de la rèagion K dans le processus d'activation metabolique conduisant au cancérogène ultime. Théorie des régions M, L, et BK
✍ Scribed by Jose Gayoso; Said Kimri
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 434 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0020-7608
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✦ Synopsis
Abstract
This study is a unified approach to quantum theories of polyacen carcinogenesis. Part II is on the role of the K‐region in metabolic activation process leading to ultimate carcinogen and discusses the M, L, and BK theory. The saturation of the polyacen K‐region, or the transformation into a quinoid one, deactivates the carcinogenic process going through a diol epoxyde, which results in Bay‐region carbocation. K and B regions must be considered as two interdependent parts of the same structural entity, which may be termed the BK‐region. The M, L, and BK theory achieves a complete unification of the Pullman and Jerina and other theories.